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Browse somatic cancers
by tissues or terms ...
NCI-60 cancer cell lines
Browse cancer-related
KEGG pathways ...
....
Find target by gene identifier
Find targets by list of
gene identifiers
Browse cancer-related
KEGG pathways
Find targets by NCI-60
gene expression ...
... using a gene identifier
... using a KEGG pathway
... using significant
gene expression in 1 to 7
single NCI-60 cell lines
Find targets by
differential gene expression ...
... within 2 NCI-60 cell lines
... from one own/external expression data set against one NCI-60 cell line
... from one own/external expression data set to
determine the the closest NCI-60 cancer cell line
... from two own/external expression data sets
(e.g., cancer/normal)
... from own/external expression data
using pre-calculated ratios
Connectivity Map ...
... explore drug influence on
differential gene expression
Find drugs ...
... by identifier
... by chemical property
... by structure
Find drugs by similarity
in growth activity of NCI-60 cancer cell lines (cellular fingerprints) ...
... using a compound identifier
... of a compound group
... manually defining a
cellular fingerprint
... defining and searching by a compound structure
Find drugs most
biologically active against
a NCI-60 cancer cell line
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doi: 10.1093/nar/gkq910
Target search: 1 gene found
Adenine phosphoribosyltransferase
(ENSG00000198931 - APRT - P07741 Q12898)
Cancer relevance of APRT (ENSG00000198931)
Cancer-related Literature
102600
(gene+phenotype)
Connectivity Map
Drug Treatment - Expression Data
ENSG00000198931
NCI-60
expression for ENSG00000198931
cancer cell lines
213892_s_at
203219_s_at
mean
NCI-60
expression of PPI partners of ...
ENSG00000198931
Drugs interacting with APRT (ENSG00000198931)
5'-deoxy-5'-thioadenosine 5'-monophosphate
DrugBank
PMID
(10 citations)
Adenine
DrugBank
PMID
(10 citations)
Drug interactions of PPI partners of ...
P07741
← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on APRT (ENSG00000198931)
Target protein
P07741 - APT_HUMAN
Description
Adenine phosphoribosyltransferase
virtual access to literature search results
P07741
Protein Identifier
APT_HUMAN
Protein Accession Number
P07741
Gene Symbol
APRT
Gene ID
ENSG00000198931
Protein ID
ENSP00000367615
Variations (Gene as map --- transcript as list)
ENSG00000198931
---
ENST00000378364
Structure Information
1ZN9
-
1ZN8
-
1ZN7
-
1ORE
-
1OPU
Domain family
Pribosyltran
Gene ID
353
virtual access to biological pathways
P07741
Protein-protein interaction (PPI) partners of ...
P07741
← P07741 Q14164 P40337 Q01433
Target protein
Q12898 - Q12898_HUMAN
virtual access to literature search results
Q12898
Protein Identifier
Q12898_HUMAN
Protein Accession Number
Q12898
Gene Symbol
APRT
Gene ID
ENSG00000198931
Protein IDs
ENSP00000367615
,
ENSP00000397007
Variations (Gene as map --- transcript as list)
ENSG00000198931
---
ENST00000378364
,
ENST00000426324
virtual access to biological pathways
Q12898