Target search: 1 gene found

Dihydropyrimidine dehydrogenase [NADP+] (ENSG00000188641 - DPYD - Q12882 A8MQU0 B4DML1 Q32NB0 Q96HL6)
Cancer relevance of DPYD (ENSG00000188641)
KEGG: Kyoto Encyclopedia of Genes and GenomesCancer-related Pathways for KEGG gene 1806 Drug metabolism - other enzymes
OMIM ® - Online Mendelian Inheritance in Man Cancer-related Literature 612779  (gene)
274270  (phenotype)
Cancer Types from drug target interaction databases breast, colon, esophageal, leukemia, liver, lung, neck, pancreatic, skin, stomach, various
Connectivity Map  info  Drug Treatment - Expression Data ENSG00000188641   info
NCI-60 expression for ENSG00000188641  info
 cancer cell lines                                                                                                                         
204646_at                                                                                                                        
ConsensusPathDB - information on physical molecular interactions, biochemical pathways, and gene regulatory networks NCI-60 expression of PPI partners of ... ENSG00000188641
Drugs interacting with DPYD (ENSG00000188641)
Amifostine PharmGKB PMID    17921712
capecitabine PharmGKB PMID    (2 citations)
CTD PMID    17611699
DrugBank PMID    (8 citations)
Carboplatin PharmGKB PMID    17921712
CTD PMID    16685392
Cisplatin PharmGKB PMID    20017672
CTD PMID    (2 citations)
docetaxel PharmGKB PMID    20157331
CTD PMID    16557585
Fluorouracil CancerResource PMID    9816071
PharmGKB PMID    (11 citations)
CTD PMID    (8 citations)
gemcitabine CTD PMID    18728667
irinotecan PharmGKB PMID    19956343
Methotrexate PharmGKB PMID    12084458
Mitoguazone CancerResource PMID    15547687
oxaliplatin PharmGKB PMID    19956343
Paclitaxel PharmGKB PMID    17921712
CTD PMID    18506536
raltitrexed PharmGKB PMID    17203168
S 1 (combination) CTD PMID    18506536
Tegafur CTD PMID    18537153
Uracil CancerResource PMID    10902627
Enfuvirtide DrugBank PMID    (8 citations)
Protein information from multiple resources on DPYD (ENSG00000188641)
Target protein Q12882 - DPYD_HUMAN
Description Dihydropyrimidine dehydrogenase [NADP+]
Synonyms DPD - Dihydrouracil dehydrogenase - Dihydrothymine dehydrogenase - DHPDHase
iHOP - Information Hyperlinked over Proteins virtual access to literature search results Q12882
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier DPYD_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number Q12882
HUGO Gene Nomenclature Committee Gene Symbol DPYD
Ensembl: gene information Gene ID ENSG00000188641
Ensembl: protein information Protein ID ENSP00000359211
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000188641 --- ENST00000370192
Pfam database - a large collection of protein families Domain families Pyr_redox_2DHO_dh
KEGG: Kyoto Encyclopedia of Genes and Genomes Gene ID 1806
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways Q12882
SYSTERS release 4 - large-scale protein clustering based on sequence similarity for the entire organism space Protein Sequence Family 139717 (for Q12882)

Target protein A8MQU0 - A8MQU0_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results A8MQU0
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier A8MQU0_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number A8MQU0
HUGO Gene Nomenclature Committee Gene Symbol DPYD
Ensembl: gene information Gene ID ENSG00000188641
Ensembl: protein information Protein IDs ENSP00000359210, ENSP00000307107
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000188641 --- ENST00000370192, ENST00000370192
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways A8MQU0

Target protein B4DML1 - B4DML1_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results B4DML1
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier B4DML1_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number B4DML1
HUGO Gene Nomenclature Committee Gene Symbol DPYD
Ensembl: gene information Gene ID ENSG00000188641
Ensembl: protein information Protein ID ENSP00000398884
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000188641 --- ENST00000370192
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways B4DML1

Target protein Q32NB0 - Q32NB0_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results Q32NB0
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier Q32NB0_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number Q32NB0
HUGO Gene Nomenclature Committee Gene Symbol DPYD
Ensembl: gene information Gene ID ENSG00000188641
Ensembl: protein information Protein ID ENSP00000307107
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000188641 --- ENST00000370192
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways Q32NB0

Target protein Q96HL6 - Q96HL6_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results Q96HL6
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier Q96HL6_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number Q96HL6
HUGO Gene Nomenclature Committee Gene Symbol DPYD
Ensembl: gene information Gene ID ENSG00000188641
Ensembl: protein information Protein ID ENSP00000307107
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000188641 --- ENST00000370192
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways Q96HL6
SYSTERS release 4 - large-scale protein clustering based on sequence similarity for the entire organism space Protein Sequence Family 139717 (for Q96HL6)