Target search: 1 gene found

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (ENSG00000171862 - PTEN - P60484 O14781 O43460)
Cancer relevance of PTEN (ENSG00000171862)
KEGG: Kyoto Encyclopedia of Genes and GenomesCancer-related Pathways for KEGG gene 5728 Endometrial cancer
Focal adhesion
Glioma
Melanoma
p53 signaling pathway
Prostate cancer
Small cell lung cancer
Tight junction
OMIM ® - Online Mendelian Inheritance in Man Cancer-related Literature 612242  (phenotype)
276950  (phenotype)
137800  (phenotype)
275355  (phenotype)
153480  (phenotype)
176920  (phenotype)
158350  (phenotype)
601728  (gene)
176807  (phenotype)
608089  (phenotype)
605309  (phenotype)
Cancer Types from drug target interaction databases breast, colon, lung, prostate, uterus, various
Connectivity Map  info  Drug Treatment - Expression Data ENSG00000171862   info
NCI-60 expression for ENSG00000171862  info
 cancer cell lines                                                                                                                         
211711_s_at                                                                                                                        
204053_x_at                                                                                                                        
204054_at                                                                                                                        
217492_s_at                                                                                                                        
mean                                                                                                                        
COSMIC - Catalogue of Somatic Mutations in Cancer NCI-60 Mutations
 cancer cell lines                                                                                                                         
Cell line link                                                                                                                        
Gene link                                                                                                                        
ConsensusPathDB - information on physical molecular interactions, biochemical pathways, and gene regulatory networks NCI-60 expression of PPI partners of ... ENSG00000171862
Drugs interacting with PTEN (ENSG00000171862)
Cisplatin PharmGKB PMID    19712441
docetaxel PharmGKB PMID    19712441
Doxorubicin CTD PMID    17359293
Fluorouracil PharmGKB PMID    16740790
gemcitabine CTD PMID    17039268
Helmoral B PharmGKB PMID    16740790
Quercetin CTD PMID    14715546
Trastuzumab PharmGKB PMID    (2 citations)
ConsensusPathDB - information on physical molecular interactions, biochemical pathways, and gene regulatory networks Drug interactions of PPI partners of ... P60484 ← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on PTEN (ENSG00000171862)
Target protein P60484 - PTEN_HUMAN
Description Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms Phosphatase and tensin homolog - Mutated in multiple advanced cancers 1
iHOP - Information Hyperlinked over Proteins virtual access to literature search results P60484
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier PTEN_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number P60484
HUGO Gene Nomenclature Committee Gene Symbol PTEN
Ensembl: gene information Gene ID ENSG00000171862
Ensembl: protein information Protein ID ENSP00000361021
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000171862 --- ENST00000371953
PDB - A Resource for Studying Biological Macromolecules Structure Information 1D5R
Pfam database - a large collection of protein families Domain families DSPcPTEN_C2
KEGG: Kyoto Encyclopedia of Genes and Genomes Gene ID 5728
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways P60484
ConsensusPathDB - information on physical molecular interactions, biochemical pathways, and gene regulatory networks Protein-protein interaction (PPI) partners of ... P60484 ← P10275 P11021 P03950 P69905 P09619 P63279 Q14764 P19784 P68400 P04637 Q05397 P03372

Target protein O14781 - O14781_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results O14781
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier O14781_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number O14781
HUGO Gene Nomenclature Committee Gene Symbol PTEN
Ensembl: gene information Gene ID ENSG00000171862
Ensembl: protein information Protein ID ENSP00000361021
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000171862 --- ENST00000371953
Pfam database - a large collection of protein families Domain families DSPcPTEN_C2
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways O14781
SYSTERS release 4 - large-scale protein clustering based on sequence similarity for the entire organism space Protein Sequence Family 139584 (for O14781)

Target protein O43460 - O43460_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results O43460
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier O43460_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number O43460
HUGO Gene Nomenclature Committee Gene Symbol PTEN
Ensembl: gene information Gene ID ENSG00000171862
Ensembl: protein information Protein ID ENSP00000361021
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000171862 --- ENST00000371953
Pfam database - a large collection of protein families Domain families DSPcPTEN_C2
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways O43460
SYSTERS release 4 - large-scale protein clustering based on sequence similarity for the entire organism space Protein Sequence Family 139584 (for O43460)