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Browse somatic cancers
by tissues or terms ...
NCI-60 cancer cell lines
Browse cancer-related
KEGG pathways ...
....
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gene identifiers
Browse cancer-related
KEGG pathways
Find targets by NCI-60
gene expression ...
... using a gene identifier
... using a KEGG pathway
... using significant
gene expression in 1 to 7
single NCI-60 cell lines
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differential gene expression ...
... within 2 NCI-60 cell lines
... from one own/external expression data set against one NCI-60 cell line
... from one own/external expression data set to
determine the the closest NCI-60 cancer cell line
... from two own/external expression data sets
(e.g., cancer/normal)
... from own/external expression data
using pre-calculated ratios
Connectivity Map ...
... explore drug influence on
differential gene expression
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... by identifier
... by chemical property
... by structure
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in growth activity of NCI-60 cancer cell lines (cellular fingerprints) ...
... using a compound identifier
... of a compound group
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doi: 10.1093/nar/gkq910
Target search: 1 gene found
Werner syndrome ATP-dependent helicase
(ENSG00000165392 - WRN - Q14191 Q59F09)
Cancer relevance of WRN (ENSG00000165392)
Cancer-related Literature
277700
(phenotype)
604611
(gene)
114500
(phenotype)
Connectivity Map
Drug Treatment - Expression Data
ENSG00000165392
NCI-60
expression for ENSG00000165392
cancer cell lines
205667_at
NCI-60
expression of PPI partners of ...
ENSG00000165392
Drugs interacting with WRN (ENSG00000165392)
Adaphostin
PDB
structure
(5 ligand interactions)
Drug interactions of PPI partners of ...
Q14191
← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on WRN (ENSG00000165392)
Target protein
Q14191 - WRN_HUMAN
Description
Werner syndrome ATP-dependent helicase
Synonyms
RecQ3 - DNA helicase, RecQ-like type 3 - RecQ protein-like 2
virtual access to literature search results
Q14191
Protein complex association
WRN-TRF2 complex
Ku70/Ku86/Werner complex
WRN-Ku70-Ku80-PARP1 complex
Protein Identifier
WRN_HUMAN
Protein Accession Number
Q14191
Gene Symbol
WRN
Gene ID
ENSG00000165392
Protein ID
ENSP00000298139
Variations (Gene as map --- transcript as list)
ENSG00000165392
---
ENST00000298139
Structure Information
2FBY
-
2FBX
-
2AXL
-
2E1E
-
3AAF
-
2FBT
-
2FC0
-
2FBV
-
2E1F
-
2DGZ
Domain families
RQC
-
DEAD
-
3_5_exonuc
-
Helicase_C
-
HRDC
Gene ID
7486
virtual access to biological pathways
Q14191
Protein-protein interaction (PPI) partners of ...
Q14191
← Q14191
Target protein
Q59F09 - Q59F09_HUMAN
virtual access to literature search results
Q59F09
Protein Identifier
Q59F09_HUMAN
Protein Accession Number
Q59F09
Gene Symbol
WRN
Gene ID
ENSG00000165392
Protein ID
ENSP00000298139
Variations (Gene as map --- transcript as list)
ENSG00000165392
---
ENST00000298139
Domain families
RQC
-
DEAD
-
Helicase_C
-
HRDC
Gene ID
7486
virtual access to biological pathways
Q59F09