Target search: 1 gene found

RAC-alpha serine/threonine-protein kinase (ENSG00000142208 - AKT1 - P31749 B0LPE5 B2RAM5 B3KVH4 B3KXD7 B7Z5R1 Q9BV07)
Cancer relevance of AKT1 (ENSG00000142208)
KEGG: Kyoto Encyclopedia of Genes and GenomesCancer-related Pathways for KEGG gene 207 Acute myeloid leukemia
Apoptosis
Chronic myeloid leukemia
Colorectal cancer
Endometrial cancer
ErbB signaling pathway
Focal adhesion
Glioma
Jak-STAT signaling pathway
MAPK signaling pathway
Melanoma
Non-small cell lung cancer
Pancreatic cancer
Prostate cancer
Renal cell carcinoma
Small cell lung cancer
T cell receptor signaling pathway
Tight junction
VEGF signaling pathway
OMIM ® - Online Mendelian Inheritance in Man Cancer-related Literature 114480  (phenotype)
604370  (phenotype)
164730  (gene)
114500  (phenotype)
Cancer Types from drug target interaction databases bone, brain, breast, colon, leukemia, lung, lymphatic, ovarian, prostate, skin, stomach, uterus, various
Connectivity Map  info  Drug Treatment - Expression Data ENSG00000142208   info
NCI-60 expression for ENSG00000142208  info
 cancer cell lines                                                                                                                         
207163_s_at                                                                                                                        
ConsensusPathDB - information on physical molecular interactions, biochemical pathways, and gene regulatory networks NCI-60 expression of PPI partners of ... ENSG00000142208
Drugs interacting with AKT1 (ENSG00000142208)
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CTD PMID    (2 citations)
7-hydroxystaurosporine CancerResource PMID    (2 citations)
Acetylcysteine CancerResource PMID    15451068
Adenosine Triphosphate DrugBank PMID    (8 citations)
alitretinoin CTD PMID    12556562
arsenic trioxide PharmGKB PMID    15316930
CTD PMID    (2 citations)
DrugBank PMID    (8 citations)
betulinic acid CancerResource PMID    16077934
CTD PMID    16077934
celecoxib PharmGKB PMID    12000750
CTD PMID    16123214
CI1033 TTD drug ID    DCL000086
combretastatin A-4 CancerResource PMID    17646428
Curcumin CTD PMID    (3 citations)
deguelin CTD PMID    (2 citations)
Cisplatin PharmGKB PMID    (2 citations)
CTD PMID    15981204
Docosahexaenoic Acids CTD PMID    17077332
Doxorubicin CTD PMID    17359293
Emodin CTD PMID    17077332
gefitinib PharmGKB PMID    18379348
gemcitabine PharmGKB PMID    19712441
imatinib CTD PMID    15786421
Indomethacin CTD PMID    17341418
Leuprolide CTD PMID    17143537
lycopene CTD PMID    17337101
Manganese CTD PMID    17043766
monodansylcadaverine CTD PMID    16170020
Nicotine PharmGKB PMID    12511591
oxaliplatin CTD PMID    19147571
Paclitaxel CTD PMID    16211241
Quercetin CTD PMID    (2 citations)
resveratrol CTD PMID    (3 citations)
Topotecan CancerResource PMID    11857382
vorinostat CTD PMID    16144943
wortmannin CTD PMID    12556562
Sorafenib PharmGKB PMID    19935717
Enzastaurin TTD drug ID    DCL000109
Perifosine CancerResource PMID    (2 citations)
Adaphostin PDB structure    (2 ligand interactions)
ConsensusPathDB - information on physical molecular interactions, biochemical pathways, and gene regulatory networks Drug interactions of PPI partners of ... P31749 ← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on AKT1 (ENSG00000142208)
Target protein P31749 - AKT1_HUMAN
Description RAC-alpha serine/threonine-protein kinase
Synonyms Protein kinase B - Proto-oncogene c-Akt - PKB - RAC-PK-alpha
iHOP - Information Hyperlinked over Proteins virtual access to literature search results P31749
CORUM - the Comprehensive Resource of Mammalian protein complexes Protein complex association eNOS-HSP90-AKT complex, VEGF induced
YBX1-AKT1 complex
AR-AKT-APPL complex
TCL1(trimer)-AKT1 complex
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier AKT1_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number P31749
HUGO Gene Nomenclature Committee Gene Symbol AKT1
Ensembl: gene information Gene ID ENSG00000142208
Ensembl: protein information Protein IDs ENSP00000384293, ENSP00000270202, ENSP00000385326
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000142208 --- ENST00000402615
PDB - A Resource for Studying Biological Macromolecules Structure Information 1UNR - 2UZR - 1UNQ - 2UZS - 3CQU - 1H10 - 3CQW - 2UVM - 1UNP
Pfam database - a large collection of protein families Domain families Pkinase_C -  PH -  Pkinase
KEGG: Kyoto Encyclopedia of Genes and Genomes Gene ID 207
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways P31749
ConsensusPathDB - information on physical molecular interactions, biochemical pathways, and gene regulatory networks Protein-protein interaction (PPI) partners of ... P31749 ← Q99683 P04049 P18031 P07900 P10275 Q92934 O15111 Q04759 O14746 P31749 P16220 P02749 P49841 Q12778 Q00987 P67775 P30153 P46527 P42345 Q05513 P42574 O15530 P12268 P63104 P45985 P12931 P28482 Q16539 P45983 P04150 P15692 P78527 Q92731 P27986 P42224 P98170 P38936 P60953 Q13153 P09601 P60484 P29474 O14757 Q01362 Q15811 P63000 P55211 P49137 P05106 P38398 P08238 P49840 P13727 O15151 O14920 P03372 P31751 P15056 Q9NQU5 P06748
Target protein B0LPE5 - B0LPE5_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results B0LPE5
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier B0LPE5_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number B0LPE5
HUGO Gene Nomenclature Committee Gene Symbol AKT1
Ensembl: gene information Gene ID ENSG00000142208
Ensembl: protein information Protein IDs ENSP00000384293, ENSP00000270202, ENSP00000385326
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000142208 --- ENST00000402615, ENST00000402615, ENST00000402615
Pfam database - a large collection of protein families Domain families Pkinase_C -  PH -  Pkinase
KEGG: Kyoto Encyclopedia of Genes and Genomes Gene ID 207
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways B0LPE5
Target protein B2RAM5 - B2RAM5_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results B2RAM5
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier B2RAM5_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number B2RAM5
HUGO Gene Nomenclature Committee Gene Symbol AKT1
Ensembl: gene information Gene ID ENSG00000142208
Ensembl: protein information Protein IDs ENSP00000384293, ENSP00000270202, ENSP00000385326
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000142208 --- ENST00000402615, ENST00000402615, ENST00000402615
Pfam database - a large collection of protein families Domain families Pkinase_C -  PH -  Pkinase
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways B2RAM5
Target protein B3KVH4 - B3KVH4_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results B3KVH4
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier B3KVH4_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number B3KVH4
HUGO Gene Nomenclature Committee Gene Symbol AKT1
Ensembl: gene information Gene ID ENSG00000142208
Ensembl: protein information Protein IDs ENSP00000384293, ENSP00000270202, ENSP00000385326
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000142208 --- ENST00000402615, ENST00000402615, ENST00000402615
Pfam database - a large collection of protein families Domain families Pkinase_C -  PH -  Pkinase
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways B3KVH4
Target protein B3KXD7 - B3KXD7_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results B3KXD7
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier B3KXD7_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number B3KXD7
HUGO Gene Nomenclature Committee Gene Symbol AKT1
Ensembl: gene information Gene ID ENSG00000142208
Ensembl: protein information Protein IDs ENSP00000384293, ENSP00000270202, ENSP00000385326
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000142208 --- ENST00000402615, ENST00000402615, ENST00000402615
Pfam database - a large collection of protein families Domain families Pkinase_C -  Pkinase
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways B3KXD7
Target protein B7Z5R1 - B7Z5R1_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results B7Z5R1
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier B7Z5R1_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number B7Z5R1
HUGO Gene Nomenclature Committee Gene Symbol AKT1
Ensembl: gene information Gene ID ENSG00000142208
Ensembl: protein information Protein IDs ENSP00000384293, ENSP00000270202, ENSP00000385326
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000142208 --- ENST00000402615, ENST00000402615, ENST00000402615
Pfam database - a large collection of protein families Domain families Pkinase_C -  Pkinase
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways B7Z5R1
Target protein Q9BV07 - Q9BV07_HUMAN
iHOP - Information Hyperlinked over Proteins virtual access to literature search results Q9BV07
UniProt - Protein knowledgebase (UniProtKB) Protein Identifier Q9BV07_HUMAN
UniProt - Protein knowledgebase (UniProtKB) Protein Accession Number Q9BV07
HUGO Gene Nomenclature Committee Gene Symbol AKT1
Ensembl: gene information Gene ID ENSG00000142208
Ensembl: protein information Protein IDs ENSP00000384293, ENSP00000270202, ENSP00000385326
Ensembl: information about variations in genes and transcripts Variations (Gene as map --- transcript as list) ENSG00000142208 --- ENST00000402615, ENST00000402615, ENST00000402615
Pfam database - a large collection of protein families Domain families Pkinase_C -  Pkinase
Reactome - a curated knowledgebase of biological pathways virtual access to biological pathways Q9BV07