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Browse somatic cancers
by tissues or terms ...
NCI-60 cancer cell lines
Browse cancer-related
KEGG pathways ...
....
Find target by gene identifier
Find targets by list of
gene identifiers
Browse cancer-related
KEGG pathways
Find targets by NCI-60
gene expression ...
... using a gene identifier
... using a KEGG pathway
... using significant
gene expression in 1 to 7
single NCI-60 cell lines
Find targets by
differential gene expression ...
... within 2 NCI-60 cell lines
... from one own/external expression data set against one NCI-60 cell line
... from one own/external expression data set to
determine the the closest NCI-60 cancer cell line
... from two own/external expression data sets
(e.g., cancer/normal)
... from own/external expression data
using pre-calculated ratios
Connectivity Map ...
... explore drug influence on
differential gene expression
Find drugs ...
... by identifier
... by chemical property
... by structure
Find drugs by similarity
in growth activity of NCI-60 cancer cell lines (cellular fingerprints) ...
... using a compound identifier
... of a compound group
... manually defining a
cellular fingerprint
... defining and searching by a compound structure
Find drugs most
biologically active against
a NCI-60 cancer cell line
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doi: 10.1093/nar/gkq910
Target search: 1 gene found
Alpha-type platelet-derived growth factor receptor
(ENSG00000134853 - PDGFRA - P16234 Q6P4H5)
Cancer relevance of PDGFRA (ENSG00000134853)
Cancer-related Pathways for KEGG gene
5156
Cytokine-cytokine receptor interaction
Focal adhesion
Glioma
MAPK signaling pathway
Melanoma
Prostate cancer
Regulation of actin cytoskeleton
Cancer-related Literature
173490
(gene)
607685
(phenotype)
Cancer Types
from drug target interaction databases
breast, pancreatic, stomach, various
Connectivity Map
Drug Treatment - Expression Data
ENSG00000134853
NCI-60
expression for ENSG00000134853
cancer cell lines
203131_at
NCI-60
expression of PPI partners of ...
ENSG00000134853
Drugs interacting with PDGFRA (ENSG00000134853)
imatinib
PharmGKB
PMID
(2 citations)
CTD
PMID
(2 citations)
DrugBank
PMID
(5 citations)
Progesterone
CTD
PMID
17614352
Sunitinib
PharmGKB
PMID
18955458
DrugBank
PMID
(5 citations)
Becaplermin
DrugBank
PMID
(5 citations)
Drug interactions of PPI partners of ...
P16234
← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on PDGFRA (ENSG00000134853)
Target protein
P16234 - PGFRA_HUMAN
Description
Alpha-type platelet-derived growth factor receptor
Synonyms
PDGF-R-alpha - CD140 antigen-like family member A - CD140a antigen
virtual access to literature search results
P16234
Protein complex association
SNX complex (SNX1,1a,2,4, PDGF receptor)
PDGF receptor complex
CRKL-PDGFRA-CRK-RAPGEF1 complex
PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated
PDGFRA-SHP-2 complex, PDGF stimulated
Protein Identifier
PGFRA_HUMAN
Protein Accession Number
P16234
Gene Symbol
PDGFRA
Gene ID
ENSG00000134853
Protein ID
ENSP00000257290
Variations (Gene as map --- transcript as list)
ENSG00000134853
---
ENST00000257290
Structure Information
1GQ5
Domain family
Pkinase_Tyr
Gene ID
5156
virtual access to biological pathways
P16234
Protein-protein interaction (PPI) partners of ...
P16234
← P16234 P09619 P42224 P23458 P51692 P40763
Target protein
Q6P4H5 - Q6P4H5_HUMAN
virtual access to literature search results
Q6P4H5
Protein Identifier
Q6P4H5_HUMAN
Protein Accession Number
Q6P4H5
Gene Symbol
PDGFRA
Gene ID
ENSG00000134853
Protein ID
ENSP00000257290
Variations (Gene as map --- transcript as list)
ENSG00000134853
---
ENST00000257290
Domain family
Pkinase_Tyr
virtual access to biological pathways
Q6P4H5