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Browse somatic cancers
by tissues or terms ...
NCI-60 cancer cell lines
Browse cancer-related
KEGG pathways ...
....
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gene identifiers
Browse cancer-related
KEGG pathways
Find targets by NCI-60
gene expression ...
... using a gene identifier
... using a KEGG pathway
... using significant
gene expression in 1 to 7
single NCI-60 cell lines
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differential gene expression ...
... within 2 NCI-60 cell lines
... from one own/external expression data set against one NCI-60 cell line
... from one own/external expression data set to
determine the the closest NCI-60 cancer cell line
... from two own/external expression data sets
(e.g., cancer/normal)
... from own/external expression data
using pre-calculated ratios
Connectivity Map ...
... explore drug influence on
differential gene expression
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... by chemical property
... by structure
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doi: 10.1093/nar/gkq910
Target search: 1 gene found
Plasminogen
(ENSG00000122194 - PLG - P00747 A6PVI2 B2R7F8 B4DPH4 Q5TEH5 Q68DS2 Q9UMI2)
Cancer relevance of PLG (ENSG00000122194)
Cancer-related Pathways for KEGG gene
5340
Complement and coagulation cascades
Neuroactive ligand-receptor interaction
Cancer-related Literature
217090
(phenotype)
173350
(gene+phenotype)
188050
(phenotype)
Connectivity Map
Drug Treatment - Expression Data
ENSG00000122194
NCI-60
expression for ENSG00000122194
cancer cell lines
209977_at
NCI-60
expression of PPI partners of ...
ENSG00000122194
Drugs interacting with PLG (ENSG00000122194)
6-Aminocaproic Acid
DrugBank
PMID
(31 citations)
cis-4-aminomethylcyclohexane-1-carboxylic acid
DrugBank
PMID
(31 citations)
Aprotinin
DrugBank
PMID
(31 citations)
Urokinase
DrugBank
PMID
(31 citations)
Adaphostin
PDB
structure
(5 ligand interactions)
Drug interactions of PPI partners of ...
P00747
← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on PLG (ENSG00000122194)
Target protein
P00747 - PLMN_HUMAN
Description
Plasminogen
Synonyms
Angiostatin - Plasmin heavy chain A, short form - Plasmin heavy chain A - Plasmin light chain B - Activation peptide
virtual access to literature search results
P00747
Protein Identifier
PLMN_HUMAN
Protein Accession Number
P00747
Gene Symbol
PLG
Gene ID
ENSG00000122194
Protein ID
ENSP00000308938
Variations (Gene as map --- transcript as list)
ENSG00000122194
---
ENST00000308192
Structure Information
1KRN
-
1HPK
-
2DOH
-
1HPJ
-
1CEB
-
1BUI
-
1PK4
-
1B2I
-
1CEA
-
5HPG
-
1I5K
-
2KNF
-
1KI0
-
1L4D
-
1PMK
-
1QRZ
-
1RJX
-
1DDJ
-
1PKR
-
2PK4
-
2DOI
-
1BML
-
1L4Z
Domain families
Trypsin
-
Kringle
-
PAN_1
Gene ID
5340
virtual access to biological pathways
P00747
Protein-protein interaction (PPI) partners of ...
P00747
← P00747 P10114 P14780 P25391 P07355 P02749 Q16787 Q16819 P01138 P13726 P35237 P09486 P00750 P05121 P07288 P04156 P01008 P00450 P08254 P01042 P05452 P07996 P00749 P02751 O15230 P05120
Target protein
A6PVI2 - A6PVI2_HUMAN
virtual access to literature search results
A6PVI2
Protein Identifier
A6PVI2_HUMAN
Protein Accession Number
A6PVI2
Gene Symbol
PLG
Gene ID
ENSG00000122194
Protein IDs
ENSP00000394561
,
ENSP00000389424
Variations (Gene as map --- transcript as list)
ENSG00000122194
---
ENST00000428851
,
ENST00000428851
Domain families
Kringle
-
PAN_1
virtual access to biological pathways
A6PVI2
Target protein
B2R7F8 - B2R7F8_HUMAN
virtual access to literature search results
B2R7F8
Protein Identifier
B2R7F8_HUMAN
Protein Accession Number
B2R7F8
Gene Symbol
PLG
Gene ID
ENSG00000122194
Protein ID
ENSP00000308938
Variations (Gene as map --- transcript as list)
ENSG00000122194
---
ENST00000308192
Domain families
Trypsin
-
Kringle
-
PAN_1
virtual access to biological pathways
B2R7F8
Target protein
B4DPH4 - B4DPH4_HUMAN
virtual access to literature search results
B4DPH4
Protein Identifier
B4DPH4_HUMAN
Protein Accession Number
B4DPH4
Gene Symbol
PLG
Gene ID
ENSG00000122194
Protein ID
ENSP00000308938
Variations (Gene as map --- transcript as list)
ENSG00000122194
---
ENST00000308192
Domain families
Trypsin
-
Kringle
virtual access to biological pathways
B4DPH4
Target protein
Q5TEH5 - Q5TEH5_HUMAN
virtual access to literature search results
Q5TEH5
Protein Identifier
Q5TEH5_HUMAN
Protein Accession Number
Q5TEH5
Gene Symbol
PLG
Gene ID
ENSG00000122194
Protein IDs
ENSP00000308938
,
ENSP00000355891
Variations (Gene as map --- transcript as list)
ENSG00000122194
---
ENST00000308192
,
ENST00000308192
Domain families
Kringle
-
PAN_1
virtual access to biological pathways
Q5TEH5
Target protein
Q68DS2 - Q68DS2_HUMAN
virtual access to literature search results
Q68DS2
Protein Identifier
Q68DS2_HUMAN
Protein Accession Number
Q68DS2
Gene Symbol
PLG
Gene ID
ENSG00000122194
Protein ID
ENSP00000308938
Variations (Gene as map --- transcript as list)
ENSG00000122194
---
ENST00000308192
Domain family
Trypsin
virtual access to biological pathways
Q68DS2
Target protein
Q9UMI2 - Q9UMI2_HUMAN
virtual access to literature search results
Q9UMI2
Protein Identifier
Q9UMI2_HUMAN
Protein Accession Number
Q9UMI2
Gene Symbol
PLG
Gene ID
ENSG00000122194
Protein ID
ENSP00000308938
Variations (Gene as map --- transcript as list)
ENSG00000122194
---
ENST00000308192
Domain family
Kringle
virtual access to biological pathways
Q9UMI2