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Browse somatic cancers
by tissues or terms ...
NCI-60 cancer cell lines
Browse cancer-related
KEGG pathways ...
....
Find target by gene identifier
Find targets by list of
gene identifiers
Browse cancer-related
KEGG pathways
Find targets by NCI-60
gene expression ...
... using a gene identifier
... using a KEGG pathway
... using significant
gene expression in 1 to 7
single NCI-60 cell lines
Find targets by
differential gene expression ...
... within 2 NCI-60 cell lines
... from one own/external expression data set against one NCI-60 cell line
... from one own/external expression data set to
determine the the closest NCI-60 cancer cell line
... from two own/external expression data sets
(e.g., cancer/normal)
... from own/external expression data
using pre-calculated ratios
Connectivity Map ...
... explore drug influence on
differential gene expression
Find drugs ...
... by identifier
... by chemical property
... by structure
Find drugs by similarity
in growth activity of NCI-60 cancer cell lines (cellular fingerprints) ...
... using a compound identifier
... of a compound group
... manually defining a
cellular fingerprint
... defining and searching by a compound structure
Find drugs most
biologically active against
a NCI-60 cancer cell line
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doi: 10.1093/nar/gkq910
Target search: 1 gene found
Interleukin-12 subunit beta
(ENSG00000113302 - IL12B - P29460 A1Z2L5 Q8N0X8)
Cancer relevance of IL12B (ENSG00000113302)
Cancer-related Pathways for KEGG gene
3593
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Cancer-related Literature
209950
(phenotype)
161561
(gene)
Cancer Types
from drug target interaction databases
prostate
Connectivity Map
Drug Treatment - Expression Data
ENSG00000113302
NCI-60
expression for ENSG00000113302
cancer cell lines
207901_at
NCI-60
expression of PPI partners of ...
ENSG00000113302
Drugs interacting with IL12B (ENSG00000113302)
Mannose
DrugBank
PMID
(9 citations)
parthenolide
CTD
PMID
16921510
thionitrobenzoic acid
DrugBank
PMID
(9 citations)
Drug interactions of PPI partners of ...
P29460
← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on IL12B (ENSG00000113302)
Target protein
P29460 - IL12B_HUMAN
Description
Interleukin-12 subunit beta
Synonyms
IL-12 subunit p40 - IL-12B - NKSF2 - NK cell stimulatory factor chain 2 - Cytotoxic lymphocyte maturation factor 40 kDa subunit - CLMF p40
virtual access to literature search results
P29460
Protein complex association
IL12A-IL12B complex
IL12A-IL12B-IL12RB1 complex
IL12B-IL12RB1-IL12RB2 complex
IL12A-IL12B-IL12RB2 complex
IL-12 heterodimer complex
IL-12 subunit p40 homodimer complex
Protein Identifier
IL12B_HUMAN
Protein Accession Number
P29460
Gene Symbol
IL12B
Gene ID
ENSG00000113302
Protein ID
ENSP00000231228
Variations (Gene as map --- transcript as list)
ENSG00000113302
---
ENST00000231228
Structure Information
1F45
-
3DUH
-
3D87
-
1F42
-
3D85
Domain family
IL12p40_C
Gene ID
3593
virtual access to biological pathways
P29460
Protein-protein interaction (PPI) partners of ...
P29460
← P29460
Target protein
A1Z2L5 - A1Z2L5_HUMAN
virtual access to literature search results
A1Z2L5
Protein Identifier
A1Z2L5_HUMAN
Protein Accession Number
A1Z2L5
Gene Symbol
IL12B
Gene ID
ENSG00000113302
Protein ID
ENSP00000231228
Variations (Gene as map --- transcript as list)
ENSG00000113302
---
ENST00000231228
virtual access to biological pathways
A1Z2L5
Target protein
Q8N0X8 - Q8N0X8_HUMAN
virtual access to literature search results
Q8N0X8
Protein Identifier
Q8N0X8_HUMAN
Protein Accession Number
Q8N0X8
Gene Symbol
IL12B
Gene ID
ENSG00000113302
Protein ID
ENSP00000231228
Variations (Gene as map --- transcript as list)
ENSG00000113302
---
ENST00000231228
virtual access to biological pathways
Q8N0X8