CancerResource
Home
Cancer
Drug
Target
Browse
About
Browse somatic cancers
by tissues or terms ...
NCI-60 cancer cell lines
Browse cancer-related
KEGG pathways ...
....
Find target by gene identifier
Find targets by list of
gene identifiers
Browse cancer-related
KEGG pathways
Find targets by NCI-60
gene expression ...
... using a gene identifier
... using a KEGG pathway
... using significant
gene expression in 1 to 7
single NCI-60 cell lines
Find targets by
differential gene expression ...
... within 2 NCI-60 cell lines
... from one own/external expression data set against one NCI-60 cell line
... from one own/external expression data set to
determine the the closest NCI-60 cancer cell line
... from two own/external expression data sets
(e.g., cancer/normal)
... from own/external expression data
using pre-calculated ratios
Connectivity Map ...
... explore drug influence on
differential gene expression
Find drugs ...
... by identifier
... by chemical property
... by structure
Find drugs by similarity
in growth activity of NCI-60 cancer cell lines (cellular fingerprints) ...
... using a compound identifier
... of a compound group
... manually defining a
cellular fingerprint
... defining and searching by a compound structure
Find drugs most
biologically active against
a NCI-60 cancer cell line
FAQ
HowTo
Statistics
Links
Contact
doi: 10.1093/nar/gkq910
Target search: 1 gene found
Glucokinase
(ENSG00000106633 - GCK - P35557 A7LFL1 C9JQD1 Q53Y25)
Cancer relevance of GCK (ENSG00000106633)
Cancer-related Literature
138079
(gene)
602485
(phenotype)
125851
(phenotype)
606391
(phenotype)
Connectivity Map
Drug Treatment - Expression Data
ENSG00000106633
NCI-60
expression for ENSG00000106633
cancer cell lines
211167_s_at
NCI-60
expression of PPI partners of ...
ENSG00000106633
Drugs interacting with GCK (ENSG00000106633)
Aclarubicin
CancerResource
PMID
9525814
Glucose
DrugBank
PMID
(19 citations)
Adaphostin
PDB
structure
(2 ligand interactions)
Drug interactions of PPI partners of ...
P35557
← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on GCK (ENSG00000106633)
Target protein
P35557 - HXK4_HUMAN
Description
Glucokinase
Synonyms
HK4 - Hexokinase type IV - Hexokinase-4 - Hexokinase-D - HK IV
virtual access to literature search results
P35557
Protein Identifier
HXK4_HUMAN
Protein Accession Number
P35557
Gene Symbol
GCK
Gene ID
ENSG00000106633
Protein ID
ENSP00000384247
Variations (Gene as map --- transcript as list)
ENSG00000106633
---
ENST00000403799
Structure Information
3FGU
-
3A0I
-
1GLK
-
1V4S
-
3F9M
-
3IMX
-
3GOI
-
3H1V
-
3FR0
-
1V4T
Domain families
Hexokinase_2
-
Hexokinase_1
Gene ID
2645
virtual access to biological pathways
P35557
Protein-protein interaction (PPI) partners of ...
P35557
← P35557 P11413
Target protein
A7LFL1 - A7LFL1_HUMAN
virtual access to literature search results
A7LFL1
Protein Identifier
A7LFL1_HUMAN
Protein Accession Number
A7LFL1
Gene Symbol
GCK
Gene ID
ENSG00000106633
Protein ID
ENSP00000384247
Variations (Gene as map --- transcript as list)
ENSG00000106633
---
ENST00000403799
Domain families
Hexokinase_2
-
Hexokinase_1
virtual access to biological pathways
A7LFL1
Target protein
C9JQD1 - C9JQD1_HUMAN
virtual access to literature search results
C9JQD1
Protein Identifier
C9JQD1_HUMAN
Protein Accession Number
C9JQD1
Gene Symbol
GCK
Gene ID
ENSG00000106633
Protein ID
ENSP00000402840
Variations (Gene as map --- transcript as list)
ENSG00000106633
---
ENST00000403799
Domain families
Hexokinase_2
-
Hexokinase_1
virtual access to biological pathways
C9JQD1
Target protein
Q53Y25 - Q53Y25_HUMAN
virtual access to literature search results
Q53Y25
Protein Identifier
Q53Y25_HUMAN
Protein Accession Number
Q53Y25
Gene Symbol
GCK
Gene ID
ENSG00000106633
Protein ID
ENSP00000384247
Variations (Gene as map --- transcript as list)
ENSG00000106633
---
ENST00000403799
Domain families
Hexokinase_2
-
Hexokinase_1
Gene ID
2645
virtual access to biological pathways
Q53Y25