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Browse somatic cancers
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NCI-60 cancer cell lines
Browse cancer-related
KEGG pathways ...
....
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gene identifiers
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Find targets by NCI-60
gene expression ...
... using a gene identifier
... using a KEGG pathway
... using significant
gene expression in 1 to 7
single NCI-60 cell lines
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differential gene expression ...
... within 2 NCI-60 cell lines
... from one own/external expression data set against one NCI-60 cell line
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(e.g., cancer/normal)
... from own/external expression data
using pre-calculated ratios
Connectivity Map ...
... explore drug influence on
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doi: 10.1093/nar/gkq910
Target search: 1 gene found
RNA-binding protein FUS
(ENSG00000089280 - FUS - P35637 A6NMX6 A8K4H1 B4DR70 B4DVJ7 Q13344 Q6IBQ5 Q8TBR3)
Cancer relevance of FUS (ENSG00000089280)
Cancer-related Literature
612160
(phenotype)
608030
(phenotype)
137070
(gene)
Cancer Types
from drug target interaction databases
breast, lung, skin, uterus
Connectivity Map
Drug Treatment - Expression Data
ENSG00000089280
NCI-60
expression for ENSG00000089280
cancer cell lines
200959_at
217370_x_at
mean
NCI-60
expression of PPI partners of ...
ENSG00000089280
Drugs interacting with FUS (ENSG00000089280)
Cisplatin
PharmGKB
PMID
(2 citations)
gefitinib
PharmGKB
PMID
18379348
Tamoxifen
CTD
PMID
16202921
Drug interactions of PPI partners of ...
P35637
← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on FUS (ENSG00000089280)
Target protein
P35637 - FUS_HUMAN
Description
RNA-binding protein FUS
Synonyms
Oncogene FUS - Translocated in liposarcoma protein - POMp75 - Oncogene TLS - 75 kDa DNA-pairing protein
virtual access to literature search results
P35637
Protein complex association
Large Drosha complex
DGCR8 multiprotein complex
Protein Identifier
FUS_HUMAN
Protein Accession Number
P35637
Gene Symbol
FUS
Gene ID
ENSG00000089280
Protein ID
ENSP00000254108
Variations (Gene as map --- transcript as list)
ENSG00000089280
---
ENST00000254108
Domain families
zf-RanBP
-
RRM_1
virtual access to biological pathways
P35637
Protein-protein interaction (PPI) partners of ...
P35637
← P49841 P52565 P10827 O15399 Q05586 P35637
Target protein
A6NMX6 - A6NMX6_HUMAN
virtual access to literature search results
A6NMX6
Protein Identifier
A6NMX6_HUMAN
Protein Accession Number
A6NMX6
Gene Symbol
FUS
Gene ID
ENSG00000089280
Protein ID
ENSP00000369594
Variations (Gene as map --- transcript as list)
ENSG00000089280
---
ENST00000380244
Domain family
RRM_1
virtual access to biological pathways
A6NMX6
Target protein
A8K4H1 - A8K4H1_HUMAN
virtual access to literature search results
A8K4H1
Protein Identifier
A8K4H1_HUMAN
Protein Accession Number
A8K4H1
Gene Symbol
FUS
Gene ID
ENSG00000089280
Protein ID
ENSP00000254108
Variations (Gene as map --- transcript as list)
ENSG00000089280
---
ENST00000254108
Domain families
zf-RanBP
-
RRM_1
virtual access to biological pathways
A8K4H1
Target protein
B4DR70 - B4DR70_HUMAN
virtual access to literature search results
B4DR70
Protein Identifier
B4DR70_HUMAN
Protein Accession Number
B4DR70
Gene Symbol
FUS
Gene ID
ENSG00000089280
Protein ID
ENSP00000378041
Variations (Gene as map --- transcript as list)
ENSG00000089280
---
ENST00000254108
Domain families
zf-RanBP
-
RRM_1
virtual access to biological pathways
B4DR70
Target protein
B4DVJ7 - B4DVJ7_HUMAN
virtual access to literature search results
B4DVJ7
Protein Identifier
B4DVJ7_HUMAN
Protein Accession Number
B4DVJ7
Gene Symbol
FUS
Gene ID
ENSG00000089280
Protein ID
ENSP00000396348
Variations (Gene as map --- transcript as list)
ENSG00000089280
---
ENST00000254108
virtual access to biological pathways
B4DVJ7
Target protein
Q13344 - Q13344_HUMAN
virtual access to literature search results
Q13344
Protein Identifier
Q13344_HUMAN
Protein Accession Number
Q13344
Gene Symbol
FUS
Gene ID
ENSG00000089280
Protein ID
ENSP00000395493
Variations (Gene as map --- transcript as list)
ENSG00000089280
---
ENST00000433338
Domain families
zf-RanBP
-
RRM_1
virtual access to biological pathways
Q13344
Target protein
Q6IBQ5 - Q6IBQ5_HUMAN
virtual access to literature search results
Q6IBQ5
Protein Identifier
Q6IBQ5_HUMAN
Protein Accession Number
Q6IBQ5
Gene Symbol
FUS
Gene ID
ENSG00000089280
Protein ID
ENSP00000254108
Variations (Gene as map --- transcript as list)
ENSG00000089280
---
ENST00000254108
Domain families
zf-RanBP
-
RRM_1
virtual access to biological pathways
Q6IBQ5
Target protein
Q8TBR3 - Q8TBR3_HUMAN
virtual access to literature search results
Q8TBR3
Protein Identifier
Q8TBR3_HUMAN
Protein Accession Number
Q8TBR3
Gene Symbol
FUS
Gene ID
ENSG00000089280
Protein ID
ENSP00000254108
Variations (Gene as map --- transcript as list)
ENSG00000089280
---
ENST00000254108
Domain families
zf-RanBP
-
RRM_1
virtual access to biological pathways
Q8TBR3