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Browse somatic cancers
by tissues or terms ...
NCI-60 cancer cell lines
Browse cancer-related
KEGG pathways ...
....
Find target by gene identifier
Find targets by list of
gene identifiers
Browse cancer-related
KEGG pathways
Find targets by NCI-60
gene expression ...
... using a gene identifier
... using a KEGG pathway
... using significant
gene expression in 1 to 7
single NCI-60 cell lines
Find targets by
differential gene expression ...
... within 2 NCI-60 cell lines
... from one own/external expression data set against one NCI-60 cell line
... from one own/external expression data set to
determine the the closest NCI-60 cancer cell line
... from two own/external expression data sets
(e.g., cancer/normal)
... from own/external expression data
using pre-calculated ratios
Connectivity Map ...
... explore drug influence on
differential gene expression
Find drugs ...
... by identifier
... by chemical property
... by structure
Find drugs by similarity
in growth activity of NCI-60 cancer cell lines (cellular fingerprints) ...
... using a compound identifier
... of a compound group
... manually defining a
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... defining and searching by a compound structure
Find drugs most
biologically active against
a NCI-60 cancer cell line
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doi: 10.1093/nar/gkq910
Target search: 2 genes found
Target entry 1:
Guanine nucleotide-binding protein G(k) subunit alpha
(ENSG00000065135 - GNAI3 - P08754 C9J2Z2 Q5TZX1)
Cancer relevance of GNAI3 (ENSG00000065135)
Cancer-related Pathways for KEGG gene
2773
Long-term depression
Tight junction
Cancer-related Literature
139370
(gene)
Cancer Types
from drug target interaction databases
prostate
Connectivity Map
Drug Treatment - Expression Data
ENSG00000065135
NCI-60
expression for ENSG00000065135
No query result. No gene or expression corresponding to input found in database ...
NCI-60
expression of PPI partners of ...
ENSG00000065135
Drugs interacting with GNAI3 (ENSG00000065135)
biochanin A
CTD
PMID
12111696
Drug interactions of PPI partners of ...
P08754
← explore drug target interactions of protein-protein-interaction partners
Protein information from multiple resources on GNAI3 (ENSG00000065135)
Target protein
P08754 - GNAI3_HUMAN
Description
Guanine nucleotide-binding protein G(k) subunit alpha
Synonyms
G(i) alpha-3
virtual access to literature search results
P08754
Protein Identifier
GNAI3_HUMAN
Protein Accession Number
P08754
Gene Symbol
GNAI3
Gene ID
ENSG00000065135
Protein ID
ENSP00000358867
Variations (Gene as map --- transcript as list)
ENSG00000065135
---
ENST00000369851
Structure Information
2IHB
-
2V4Z
-
2ODE
Domain family
G-alpha
Gene ID
2773
virtual access to biological pathways
P08754
Protein-protein interaction (PPI) partners of ...
P08754
← P16473 P49286 P48039
Target protein
C9J2Z2 - C9J2Z2_HUMAN
virtual access to literature search results
C9J2Z2
Protein Identifier
C9J2Z2_HUMAN
Protein Accession Number
C9J2Z2
Gene Symbol
GNAI3
Gene ID
ENSG00000065135
Protein IDs
ENSP00000343027
,
ENSP00000358867
,
ENSP00000391439
Variations (Gene as map --- transcript as list)
ENSG00000065135
---
ENST00000351004
,
ENST00000369851
,
ENST00000369851
virtual access to biological pathways
C9J2Z2
Target protein
Q5TZX1 - Q5TZX1_HUMAN
virtual access to literature search results
Q5TZX1
Protein Identifier
Q5TZX1_HUMAN
Protein Accession Number
Q5TZX1
Gene Symbol
GNAI3
Gene ID
ENSG00000065135
Protein ID
ENSP00000358867
Variations (Gene as map --- transcript as list)
ENSG00000065135
---
ENST00000369851
Domain family
G-alpha
Gene ID
2773
virtual access to biological pathways
Q5TZX1
Target entry 2:
(ENSG00000127955 - GNAI3 - C9J2Z2)
Cancer relevance of GNAI3 (ENSG00000127955)
Cancer Types
from drug target interaction databases
prostate
Connectivity Map
Drug Treatment - Expression Data
ENSG00000127955
NCI-60
expression for ENSG00000127955
No query result. No gene or expression corresponding to input found in database ...
NCI-60
expression of PPI partners of ...
ENSG00000127955
Drugs interacting with GNAI3 (ENSG00000127955)
biochanin A
CTD
PMID
12111696
Protein information from multiple resources on GNAI3 (ENSG00000127955)
Target protein
C9J2Z2 - C9J2Z2_HUMAN
virtual access to literature search results
C9J2Z2
Protein Identifier
C9J2Z2_HUMAN
Protein Accession Number
C9J2Z2
Gene Symbol
GNAI3
Gene ID
ENSG00000127955
Protein IDs
ENSP00000343027
,
ENSP00000358867
,
ENSP00000391439
Variations (Gene as map --- transcript as list)
ENSG00000127955
---
ENST00000351004
,
ENST00000369851
,
ENST00000369851
virtual access to biological pathways
C9J2Z2